This entry is part of the Nutri Tailor Health Reference Library — cited research on supplements, nutrients and adjacent areas of health.
Three numbers matter and they are not the same number. Many labs flag ferritin only below about 15 micrograms per litre, a threshold set from decades-old expert opinion that newer physiological analyses put nearer 25 for women. UK clinical guidance counts ferritin below 30 as iron deficiency in adults. And the fatigue evidence reaches higher still: in the randomised trial, menstruating women with unexplained fatigue, normal haemoglobin and ferritin under 50 cut their fatigue scores by about 48% on twelve weeks of iron against 29% on placebo. Above 50, no trial establishes an optimal target, whatever number a clinic quotes. Ferritin also rises with inflammation, so a normal result during illness can mislead.
Enter what you have. Your ferritin alone works; the other fields sharpen the reading. Nothing you enter leaves this device. Nothing is saved. No AI is used, only published UK guideline thresholds.
This tool gives educational interpretation of published evidence. It is not personal dosing advice and it does not diagnose. It knows nothing about your history, symptoms or other results. Interpreting your results over time, alongside everything else about you, is what Nutri365 does.
Ferritin is the storage protein for iron, and serum ferritin broadly tracks total iron stores, which is why it is the single most useful first marker. Two things break the simple reading. First, stores run down long before haemoglobin falls, so fatigue and other symptoms can be iron-related while the full blood count still looks normal. Second, ferritin is an acute-phase protein: infection and inflammation push it up, so a reassuring number during or after illness can hide depleted stores, which is why UK guidance pairs ferritin with an inflammation check.
The trial that defines the fatigue zone used 80mg of elemental iron daily for twelve weeks in women with ferritin under 50 and normal haemoglobin, with fatigue scores falling about 48% against 29% on placebo (Vaucher 2012); quality of life, mood and anxiety scores did not separate, and the trial was manufacturer sponsored, both worth knowing. Correction dosing and duration for confirmed deficiency has its own entries in this library, and prescribed regimens belong with the GP.
The marker question comes before the product question. Once a genuine gap is confirmed, the which-form iron buying guide in this library covers the supplement side, and pairing iron with vitamin C works in your favour at the meal.
Retest timing matters more than dose timing here: stores rebuild over months, and UK practice rechecks bloods at around four weeks and again at three months after starting iron. Test before supplementing where possible, because a supplemented result is not a clean baseline, and morning samples away from acute illness give the most honest ferritin.
Iron is the one common supplement where topping up blind carries real downside: unneeded iron accumulates, and a high ferritin has its own meanings that need a GP, not a supplement. That is why the sequence is test, interpret with the inflammation caveat, then act. The Blood Result Interpreter on this page reads a ferritin alongside transferrin saturation and CRP for exactly this reason.
Menstruating women, especially with heavy periods, are the group the fatigue trial actually studied and the group most often sitting in the 15 to 50 zone. Pregnancy runs on different thresholds and belongs with the midwife. Endurance runners deplete faster. Persistent fatigue with a normal panel still deserves a GP conversation, because iron is one explanation among several.
Interpretation interactions rather than supplement ones: inflammation and infection raise ferritin, so a raised CRP invalidates a reassuring result, covered in the dedicated entry on inflammation and ferritin. Tea and coffee near meals quietly cut iron absorption, which matters when rebuilding stores; that has its own entry too.
British Society of Gastroenterology guidance (Snook 2021, Gut): serum ferritin is the key first marker, iron deficiency in most adults is identified at ferritin below 30 micrograms per litre, and ferritin should be interpreted alongside an inflammation check because it behaves as an acute-phase protein. Vaucher 2012, randomised controlled trial in 198 women: ferritin under 50 with normal haemoglobin and unexplained fatigue, twelve weeks of 80mg elemental iron, fatigue down 48% versus 29% on placebo. Mei 2023: the widely used lab thresholds for women derive from decades-old expert opinion, with physiologically based analyses supporting a higher cut-off near 25.
Read your own number in four bands. Below 15: most labs flag this and it is a GP conversation about cause as well as correction. 15 to 30: UK clinical guidance calls this deficiency in adults even where the lab report reads normal, so do not let a normal flag close the question. 30 to 50: the honest grey zone; if unexplained fatigue is real and haemoglobin is normal, this is the range where the trial found iron helped, and a GP conversation covering diet, losses and a monitored trial of iron is reasonable. Above 50: no trial establishes a higher optimal, and chasing 70 or 100 on clinic folklore is supplementing without evidence. The interpreter on this page runs these rules against your own result.
That a result inside the reference range settles it: the lab flag level and the clinical deficiency threshold are different numbers, and UK guidance sits at 30. That more ferritin is always better: above 50 the evidence for pushing higher runs out, and a genuinely high ferritin is a GP matter, not an achievement. That ferritin during a cold means what it says: inflammation inflates it, which is why the CRP check exists.