This entry is part of the Nutri Tailor Health Reference Library — cited research on supplements, nutrients and adjacent areas of health.
Every day, at a time you will not forget, is what matters; the clock is a footnote. Creatine works by filling muscle stores over weeks, not by acting on the day you take it, so a dose you never miss beats a perfectly timed one you skip. The trials that compared before with after training found a small edge for after, with a meal containing carbohydrate and protein, which is a sensible habit rather than a rule. On rest days take it with any meal, and take it with food rather than in plain water on an empty stomach if it unsettles you.
3 to 5 g a day without gaps. Stores fall over about four weeks if you stop, so a missed day is nothing and a missed fortnight starts the clock again.
Any time, every day, is what matters; the clock is a detail. Creatine works by filling muscle stores over weeks, not by acting on the day you take it, so a dose you never miss beats a perfectly timed one you forget. The few trials that compared before with after training found a small edge for after, alongside a meal with carbohydrate and protein, which is a reasonable habit rather than a rule. On rest days take it with any meal.
With food, and ideally with carbohydrate, because the insulin response nudges more creatine into muscle and food reduces the stomach upset some people get from a dose in plain water. It dissolves better in warm liquid. Coffee does not cancel it, despite the old worry.
From the Nutri Tailor range: [micronised creatine monohydrate powder](/products/creatine-micronised-monohydrate-powder), 5 g per scoop; [creatine capsules](/products/motion-nutrition-creatine), 3 g per four capsules, all made in the UK. This is a summary of published research, not personal health advice. Talk to your GP or a registered nutritional therapist before changing what you take, especially if you are pregnant, have a diagnosed condition or are under ongoing care.
That the hour matters more than the habit: for creatine the daily total and the weeks of use decide the result. That an empty stomach is always better: for creatine the answer is above, and comfort keeps people taking it.