SAMe
Support mood, joint comfort and liver function with S adenosylmethionine
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100ml
20 day supply
per day
Guaranteed additive free
Highest purity
Therapeutically effective
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Have questions about SAMe?
"I've heard SAMe helps with both mood and joints. How does that work?"
"I'm on antidepressants. Can I combine this with my medication?"
"My homocysteine is high. Is SAMe safe for me or will it make it worse?"
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Support mood, joint comfort and liver function with S adenosylmethionine
S Adenosyl L Methionine (SAMe) is a naturally occurring molecule found in every cell that serves as the body's primary methyl donor, participating in over 100 methylation reactions. Each 5ml spoonful provides 50mg of SAMe in a liquid format (purified water base). SAMe is involved in three critical metabolic pathways: methylation (gene expression, neurotransmitter metabolism, detoxification), transsulfuration (glutathione production) and aminopropylation (polyamine synthesis for cell growth).
SAMe has been extensively studied for mood support, joint comfort and liver health. In the methylation cycle, SAMe donates its methyl group to produce neurotransmitters including serotonin, dopamine and noradrenaline. SAMe is involved in methylation and has been studied for its role in supporting a balanced mood. For joints, SAMe supports cartilage proteoglycan production. For the liver, it supports glutathione synthesis and phospholipid methylation essential for bile flow and hepatocyte membrane integrity. The liquid format provides better stability than many tablet forms, as SAMe is inherently unstable and degrades quickly when exposed to moisture.
Key benefits:
- Better mood and emotional balance
- Joint comfort and cartilage support
- Liver methylation and detox
| 5ml spoonful contains: | Amount | %NRV* |
|---|---|---|
| S-Adenosyl-L-Methionine | 50 mg | † |
† Nutrient Reference Value (NRV*) not established
Purified Water, S- Adenosyl-L-Methionine.
Directions for use:
Take 1 x 5ml spoonful per day mixed into water, with food.
SAMe is best taken in the morning, as its effects on neurotransmitter production can be mildly stimulating. Mixing into a small glass of water ensures even distribution. Taking with food improves tolerability.
For mood support, allow 2 to 4 weeks to assess the effect. SAMe works within the methylation cycle and benefits from adequate B12, folate and B6 status. If using SAMe for mood, ensure these B vitamins are also being supplemented, as they are cofactors in the same pathway. Store refrigerated after opening to preserve stability.
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Suitable for men.
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Suitable for women.
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Suitable for people under sixteen years of age.
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If pregnant or breastfeeding consult your healthcare professional before purchasing and consuming this product.
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Suitable for vegetarians.
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Suitable for vegans.
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No gluten containing ingredients.
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No nut containing ingredients.
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No dairy containing ingredients.
If you are taking medication consult your prescribing physician before purchasing and consuming supplements.
Store in a cool dry place.
Keep out of reach of children.
Information displayed does not constitute medical advice.
This product should not be used as a substitute for a varied diet.
Once opened, consume within 3 months.
Quality promise
Why clinical grade matters
- ✓ GMP certified, pharmaceutical grade manufacturing
- ✓ Made in UK cleanroom facilities, ISO 9001 & ISO 14001 accredited
- ✓ No fillers, binders or additives — only active ingredients
- ✓ Fully traceable from raw material to finished product
- ✓ Non-GM, non-irradiated, 100% green energy manufacturing
Evidence
What the research shows
Our Health Reference Library is an ever-growing collection of peer-reviewed research and health guidance.
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Frequently asked questions
How does SAMe support mood?
SAMe supports neurotransmitter production and emotional balance.
When should I take mood support?
Follow label directions for optimal timing.
Can I take this with prescription medications?
Consult your provider, especially if taking antidepressants.
How do nutrients affect mood?
B vitamins, omega-3s, magnesium, and amino acids are building blocks for neurotransmitters like serotonin and dopamine.
Why is gut health linked to mood?
90% of serotonin is made in the gut. Gut inflammation and dysbiosis directly affect brain chemistry and mood.
How long until I feel better?
Some notice improvements within 1-2 weeks. Significant mood changes typically take 4-8 weeks of consistent support.
