Methyltetrahydrofolate
Support methylation and cellular function with active folate for MTHFR gene variations
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60 capsules
60 day supply
per day
Guaranteed additive free
Highest purity
Therapeutically effective
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Have questions about Methyltetrahydrofolate?
"My doctor prescribed folic acid. Is this better?"
"I have an MTHFR mutation. What dose do I actually need?"
"Can I take this during pregnancy instead of standard folic acid?"
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Support methylation and cellular function with active folate for MTHFR gene variations
This is folate in its most bioactive form: 5 methyltetrahydrofolate (5 MTHF), provided as calcium L methylfolate at 1000mcg (500% NRV) per capsule. Unlike standard folic acid (the synthetic form found in most supplements and fortified foods), methylfolate does not require conversion by the enzyme MTHFR before the body can use it. This is significant because an estimated 30 to 40% of the population carry genetic variants of the MTHFR gene that reduce their ability to convert folic acid into its active form.
For these individuals, taking standard folic acid may result in unmetabolised folic acid circulating in the blood without providing the folate dependent functions the body needs: DNA synthesis and repair, methylation (critical for gene expression, detoxification and neurotransmitter production), red blood cell formation and homocysteine clearance. At 1000mcg, this provides a beneficial dose appropriate for preconception, pregnancy, MTHFR support, mood support and homocysteine management. The capsule contains cellulose filler and a vegetarian capsule shell.
Key benefits:
- Active folate for MTHFR variations
- Better methylation and cell repair
- Mood support via neurotransmitters
| Each capsule contains: | %NRV* | |
|---|---|---|
| Folate | 1000 mcg | 500% |
† Nutrient Reference Value (NRV*) not established
Cellulose, Hydroxypropyl Methylcellulose (capsule), Calcium L-Methyl Folate.
Directions for use:
Take 1 capsule per day with food.
This product is suitable for anyone who needs folate supplementation but wants to bypass the conversion step required by folic acid. It is particularly relevant for those who know they carry MTHFR variants (C677T or A1298C), those with elevated homocysteine, women planning pregnancy, and those using folate for mood or methylation support.
If taking alongside vitamin B12, ensure the B12 is also in its active form (methylcobalamin or adenosylcobalamin) for consistent methylation support. Folate and B12 work together in the methylation cycle and should ideally be supplemented as a pair when either is taken at beneficial doses.
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Suitable for men.
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Suitable for women.
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Suitable for people under sixteen years of age.
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If pregnant or breastfeeding consult your healthcare professional before purchasing and consuming this product.
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Suitable for vegetarians.
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Suitable for vegans.
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No gluten containing ingredients.
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No nut containing ingredients.
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No dairy containing ingredients.
If you are taking medication consult your prescribing physician before purchasing and consuming supplements.
Store in a cool dry place.
Keep out of reach of children.
Information displayed does not constitute medical advice.
This product should not be used as a substitute for a varied diet.
Once opened, consume within 3 months.
Quality promise
Why clinical grade matters
- ✓ GMP certified, pharmaceutical grade manufacturing
- ✓ Made in UK cleanroom facilities, ISO 9001 & ISO 14001 accredited
- ✓ No fillers, binders or additives — only active ingredients
- ✓ Fully traceable from raw material to finished product
- ✓ Non-GM, non-irradiated, 100% green energy manufacturing
Evidence
What the research shows
Our Health Reference Library is an ever-growing collection of peer-reviewed research and health guidance.
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Frequently asked questions
Why take Methyltetrahydrofolate?
Methyltetrahydrofolate supports energy production, nervous system function, and stress resilience.
When should I take B vitamins?
Take in the morning with food to support energy throughout the day.
What are signs of B vitamin deficiency?
Common signs include fatigue, brain fog, mood changes, and numbness.
What does methylated mean?
Methylated B vitamins are pre-activated forms your body can use immediately. Important for those with MTHFR gene variations.
Can B vitamins cause anxiety?
Some people are sensitive to certain B vitamins. Start with a lower dose and take with food if you notice overstimulation.
Why do B vitamins turn urine yellow?
Riboflavin (B2) causes bright yellow urine. This is harmless and shows the vitamins are being processed.
