Vitamin B12 Adenosylcobalamin Capsules

Each capsule provides 1000mcg of vitamin B12 as adenosylcobalamin, the mitochondrial form of B12 that is active as a cofactor for the enzyme methylmalonyl CoA mutase. This enzyme is essential for the metabolism of odd chain fatty acids and certain amino acids (valine, isoleucine, methionine, threonine) within the mitochondria for energy production. When adenosylcobalamin is insufficient, methylmalonic acid (MMA) accumulates, which is used clinically as a specific marker of functional B12 deficiency.

Adenosylcobalamin is the less commonly supplemented of the two active B12 forms (the other being methylcobalamin), yet it is equally important. While methylcobalamin supports methylation in the cytoplasm, adenosylcobalamin supports energy production in the mitochondria. Symptoms of adenosylcobalamin deficiency include fatigue, muscle weakness and neurological symptoms, even when methylcobalamin levels are adequate. At 1000mcg per capsule, this provides a therapeutic dose for those specifically targeting mitochondrial B12 function. The vegetarian capsule shell makes this suitable for most dietary requirements.