Vitamin B2 R5P Capsules

Support energy metabolism with active riboflavin (R5P), studied in the context of migraine

Each capsule provides 47.5mg of vitamin B2 as riboflavin 5 phosphate (R5P), the active coenzyme form that the body uses directly without requiring hepatic conversion. Standard riboflavin must be phosphorylated in the liver to become R5P before it can function as a cofactor for flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), the two flavocoenzymes involved in energy production, antioxidant defence and the metabolism of other B vitamins.

R5P is a cofactor for the MTHFR enzyme (connecting riboflavin directly to methylation capacity), glutathione reductase (recycling oxidised glutathione back to its active reduced form) and the electron transport chain (mitochondrial energy production). Riboflavin at doses of 200 to 400mg daily has specific evidence for migraine prevention. At 47.5mg per capsule, the dose can be scaled from maintenance to beneficial levels. The vegetarian capsule shell makes this suitable for most dietary requirements. Note: vitamin B2 turns urine bright yellow, which is harmless and indicates absorption.

Key benefits:

• Energy metabolism and less fatigue
• Fewer migraines clinically shown
• Active form ready for use

† Nutrient Reference Value (NRV*) not established

Cellulose, Riboflavin 5 Phosphate, Hydroxypropyl Methylcellulose (capsule).

Directions for use:

Take 1 capsule per day with food.

For general maintenance and methylation support, 1 capsule daily is appropriate. For migraine prevention, higher doses (up to 400mg daily, approximately 8 capsules) are used in clinical research, though this should be guided by a healthcare professional. The R5P form is particularly important for those with liver dysfunction or MTHFR variants, as both conditions can impair the conversion of standard riboflavin to its active form.