Vitamin B6 P5P Capsules (Pyridoxal 5-Phosphate)

P5P capsules, in stock in the UK. Nutri Tailor stocks pyridoxal 5-phosphate (P5P), the active form of vitamin B6, as a capsule, 34 mg per capsule, in pots of 60 and 120, shipped from the UK.

P5P only, the active form of B6. These capsules contain pyridoxal 5-phosphate as their sole form of vitamin B6, not pyridoxine hydrochloride. For a small, adjustable dose see Vitamin B6 P5P Liquid at 848 mcg per drop, or B Complex Liquid for P5P alongside the other B vitamins.

• 34 mg P5P per capsule (2429% NRV)
• 60 or 120 capsules, one per day
• Vegetarian capsule shell, vegan, gluten free, dairy free, nut free
• Made in the UK under GMP

Ships worldwide from the UK, with duties and taxes shown upfront at checkout.

What P5P is. Pyridoxal 5-phosphate is vitamin B6 already converted into its coenzyme form, the form the body uses in well over a hundred enzyme reactions covering amino acid metabolism, neurotransmitter synthesis, haemoglobin formation, homocysteine handling and the release of stored glycogen. Pyridoxine hydrochloride, the standard supplement form, has to be converted in the liver into P5P first; these capsules give you the converted form.

How it differs from pyridoxine. Both raise B6 status, and head-to-head evidence that P5P works better in people is thin. The fair case for P5P rests on dose safety: the sensory nerve problems reported with sustained high-dose pyridoxine are linked in laboratory work to pyridoxine competing with the active P5P form. Dose matters more than form, and this is a higher-dose product: the NHS advises not going above 10 mg a day long term unless a doctor advises it, and in 2023 EFSA lowered its adult ceiling to 12 mg a day. At 34 mg a capsule, this product suits a short course or a practitioner's instruction, not open-ended daily use.

Who chooses it. People who have been told by a practitioner or their GP to take B6 at a higher dose for a set period. People with a tested low level. People who want the active form rather than pyridoxine at that dose. Vitamin B6 contributes to the regulation of hormonal activity, normal psychological function, normal functioning of the nervous system, normal energy-yielding metabolism, normal homocysteine metabolism, normal red blood cell formation and the reduction of tiredness and fatigue.

Capsules or drops. The capsule gives a fixed 34 mg. The liquid gives 848 mcg per drop, under 1 mg, and lets you build the dose one drop at a time while staying near the 10 mg long-term guidance figure. If you have not been told to take a higher dose, the drops are the right product.

How to take it. One capsule daily with food, for the period you have been advised. Morning with food suits most people. New tingling or numbness in the hands or feet means stop and speak to your GP. The Nutri Tailor guide Which form of vitamin B6 should you buy: P5P or pyridoxine? covers the evidence and the dose question in more detail.

* Nutrient Reference Value

Cellulose, Pyridoxal 5 Phopshate Hydroxypropyl Methylcellulose (capsule).

Directions for use:

Take 1 capsule per day with food.

Take with a meal. At 34 mg a capsule this product sits above the 10 mg a day the NHS advises as a long-term limit unless a doctor says otherwise, and above the 12 mg a day ceiling EFSA set in 2023, so use it for the period you have been advised rather than indefinitely. New tingling or numbness in the hands or feet means stop and speak to your GP.

For methylation routines it pairs with methylfolate and methylcobalamin.